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Related Concept Videos

Vesicular Trasport: Endocytosis, Transcytosis and Exocytosis01:18

Vesicular Trasport: Endocytosis, Transcytosis and Exocytosis

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Vesicular transport is a cellular process that encompasses the engulfment of particles or dissolved substances by cells. It involves endocytosis, transcytosis, and exocytosis.
Endocytosis is a cellular mechanism that involves the inward folding of the cell membrane to create vesicles that capture and transport large drug molecules. This process comprises two distinct methods: pinocytosis (often referred to as "cell drinking") and phagocytosis (often referred to as "cell...
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The Significance of Membrane Transport01:44

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The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
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The Significance of Membrane Transport01:44

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Transport Across the Golgi01:26

Transport Across the Golgi

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While it is unclear how molecules move between adjacent Golgi cisternae, it is apparent that the molecules move from cis- cisterna, the entry face, to the trans- cisterna, the exit face. Experiments initially suggested vesicles that bud from one cisterna and fuse with the next cisterna to transport proteins between the cisternae. This vesicular transport model describes the Golgi apparatus as a relatively static structure with a unique enzyme composition in each cisterna. Molecules are...
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ABC Transporters: Exporter01:31

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ATP-binding cassette or ABC transporter is the largest superfamily of integral membrane proteins. The transporters have transmembrane-binding domains (TMDs) and nucleotide-binding domains (NBDs). The TMDs are specific to their substrates, whereas the NBDs are similar to engines that complete ATP hydrolysis to complete the substrate transport. They can be full transporters consisting of two TMDs and NBDs, half transporters with one TMD and NBD, while some encoded with a single TMD or NBD are...
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Protein Transport into the Inner Mitochondrial Membrane01:34

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Nuclear encoded mitochondrial precursors are imported to the inner membrane in a multistep process involving two separate translocons, TIM22 and TIM23. TIM23 is a cation-selective pore that remains closed by the N terminal segment of the protein. Negative charges on the TIM23 act as a receptor for the incoming precursor, pulling the positively charged matrix-targeting sequence for peptide insertion and translocation.
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Related Experiment Video

Updated: May 4, 2026

Selection of Transporter-Targeted Inhibitory Nanobodies by Solid-Supported-Membrane SSM-Based Electrophysiology
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Vesicular transport earns a Nobel.

Juan S Bonifacino1

  • 1Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

Trends in Cell Biology
|December 31, 2013
PubMed
Summary

The 2013 Nobel Prize recognized key discoveries in vesicular transport, a vital process for moving molecules within cells. This work inspires future research into intracellular compartmentalization and dynamics.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Physiology

Background:

  • Intracellular traffic is essential for cellular function.
  • Vesicular transport facilitates the movement of molecules within cells.
  • Understanding these mechanisms is crucial for cell biology.

Purpose of the Study:

  • To highlight the significance of the 2013 Nobel Prize winners' discoveries.
  • To emphasize the molecular mechanisms of vesicular transport.
  • To inspire future research in intracellular dynamics.

Main Methods:

  • Not applicable for this abstract; focuses on a scientific award and its implications.
  • The abstract does not detail specific experimental methods.
  • It summarizes the impact of awarded research.

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Characterization of Membrane Transporters by Heterologous Expression in E. coli and Production of Membrane Vesicles
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Expression, Solubilization, and Purification of Eukaryotic Borate Transporters
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Related Experiment Videos

Last Updated: May 4, 2026

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Characterization of Membrane Transporters by Heterologous Expression in E. coli and Production of Membrane Vesicles
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Expression, Solubilization, and Purification of Eukaryotic Borate Transporters
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Main Results:

  • The 2013 Nobel Prize in Physiology or Medicine was awarded for discoveries in molecular mechanisms of vesicular transport.
  • This research elucidated fundamental principles of how cells move cargo.
  • The work has broad implications for understanding cellular processes.

Conclusions:

  • The discoveries by Rothman, Schekman, and Südhof represent a major advancement in cell biology.
  • This foundational work provides a basis for further exploration of intracellular processes.
  • The field of intracellular traffic continues to evolve, driven by these insights.