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Peripapillary ring: histology and correlations.

Jost B Jonas1, Leonard Holbach, Songhomitra Panda-Jonas

  • 1Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Acta Ophthalmologica
|December 31, 2013
PubMed
Summary
This summary is machine-generated.

The peripapillary ring (PPR) width slightly increases with longer axial length and is not associated with glaucoma. This optic disc boundary structure correlates with pia mater thickness and extends to the ocular surface.

Keywords:
Bruch′s membranearterial circle Zinn-Hallerglaucomalamina cribrosamyopiaoptic discoptic nerve headperipapillary ringperipapillary scleral flange

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Area of Science:

  • Ophthalmology
  • Anatomy
  • Histology

Background:

  • The peripapillary ring (PPR) is a key anatomical landmark at the optic disc boundary.
  • Understanding its histologic correlate is crucial for interpreting optic nerve head morphology.

Purpose of the Study:

  • To histologically define the peripapillary ring (PPR) as the optic disc boundary.
  • To perform histomorphometric measurements of the PPR.
  • To investigate associations between PPR width, glaucoma, and axial length.

Main Methods:

  • Histologic examination of 83 human globes using light microscopy.
  • Measurement of peripapillary ring (PPR) width and optic nerve pia mater thickness.
  • Measurement of axial length, parapapillary beta and gamma zones, and scleral/choroidal thickness.

Main Results:

  • Mean PPR width was 55 ± 14 μm; it increased with axial length (r=0.35, p=0.001) and peripapillary scleral flange length (r=0.34, p=0.02).
  • Pia mater thickness (52 ± 22 μm) correlated with PPR width (r=0.37, p=0.001), axial length (r=0.24, p=0.03), and glaucoma presence (p=0.03).
  • PPR's histologic appearance varied based on the presence of the parapapillary gamma zone, relating to Bruch's membrane and retinal nerve fiber layer attachments.

Conclusions:

  • Peripapillary ring (PPR) width is a measurable histologic feature, slightly increasing with axial length and independent of glaucoma.
  • PPR width is strongly correlated with optic nerve pia mater thickness.
  • The PPR represents the continuation of the pia mater to the ocular surface, defining the optic disc boundary.