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Analytical Techniques for Assaying Nitric Oxide Bioactivity
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Analytical Techniques for Assaying Nitric Oxide Bioactivity

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Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors

Mariangela Biava1, Claudio Battilocchio1, Giovanna Poce1

  • 1Dipartimento di Chimica e Tecnologie del Farmaco, Università degli Studi di Roma "La Sapienza", Piazzale Aldo Moro 5, 00185 Roma, Italy.

Bioorganic & Medicinal Chemistry
|December 31, 2013
PubMed

Keywords:
(t)NSAIDs1,5-Diarylpyrroles1-ethyl-3-(3-dimethylaminopropyl)carbodiimide1-hydroxybenzotriazole1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-oneAABocCBzCINODsCOX-2CVCoxibsCyclooxygenasesDMAPDMEMDulbecco’s modified eagle’s mediumE(max)EDCIFBSGIHOBtHWBLPSNONO releasing moiety (nitroxy)butanolNOBANSAIDsNitric oxideOAODQPBSPGE(2)Pharmacodynamic hybridsPyBOPRARIASARSGFTXarachidonic acidbenzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphatecNOScarboxybenzylcardiovascularconstitutive nitric oxide synthasescoxibscyclooxygenase 2cyclooxygenase-2 inhibitorscyclooxygenase-inhibiting nitric oxide donordimethylaminopyridinefetal bovine serumgastrointestinalhuman whole bloodintraperitonealintraplantaripipllipopolysaccharidemaximal vasorelaxing responsenitric oxidenonsteroidal anti-inflammatory drugosteoarthritisphosphate buffer solutionprostaglandin E(2)radioimmunoassayrheumatoid arthritissimulated gastric fluidstructure relationship studiestert-butyloxycarbonylthromboxanetraditional nonsteroidal anti-inflammatory drug

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