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MicroRNAs affect BCL-2 family proteins in the setting of cerebral ischemia

Yi-Bing Ouyang1, Rona G Giffard1

  • 1Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA.

Neurochemistry International
|December 31, 2013
PubMed

Insights

The BCL-2 family regulates apoptosis and calcium (Ca2+) transmission in cerebral ischemia. MicroRNAs, like miR-29, target these proteins, influencing outcomes after stroke.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

Background:

  • The BCL-2 protein family is crucial for regulating apoptosis and cell death following cerebral ischemia.
  • These proteins control mitochondrial outer membrane permeabilization, a key step in programmed cell death.
  • Emerging evidence implicates BCL-2 family members in regulating calcium (Ca2+) transmission at mitochondria-associated ER membranes (MAM).

Purpose of the Study:

  • To review the multifaceted roles of BCL-2 family proteins in cerebral ischemia.
  • To summarize the known relationship between BCL-2 family proteins and stroke outcomes.
  • To highlight the regulatory role of microRNAs (miRNAs) targeting BCL-2 family proteins in cerebral ischemia.

Main Methods:

  • Literature review of existing research on BCL-2 family proteins, cerebral ischemia, and miRNAs.
  • Focus on studies investigating the interaction between miRNAs and BCL-2 family members.
  • Analysis of the specific role of miR-29 in targeting BCL-2 family proteins.

Main Results:

  • BCL-2 family proteins are central to apoptotic mechanisms after cerebral ischemia.
  • These proteins also influence Ca2+ signaling between the endoplasmic reticulum and mitochondria via MAM.
  • miRNAs, particularly miR-29, are increasingly recognized for their regulatory impact on BCL-2 family proteins in the context of cerebral ischemia.

Conclusions:

  • BCL-2 family proteins play a dual role in cerebral ischemia, affecting both apoptosis and calcium homeostasis.
  • miRNAs, especially miR-29, represent a significant regulatory layer for BCL-2 family proteins in stroke.
  • Understanding these interactions is vital for developing novel therapeutic strategies for cerebral ischemia.
Keywords:
BCL-2Cerebral ischemiaStrokemiR-29microRNA

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