Nutrition, diet and immunosenescence
Mònica Maijó1, Sarah J Clements1, Kamal Ivory1
1Gut Health & Food Safety Research Programme, Institute of Food Research, Norwich, UK.
Mechanisms of Ageing and Development
|December 31, 2013
Summary
Aging leads to immunosenescence, a decline in immune function increasing infection risk. Nutritional interventions may help delay this process and improve elderly quality of life.
Area of Science:
- Immunology
- Gerontology
- Nutrition Science
Background:
- Aging is associated with immunosenescence, a decline in immune system function.
- This decline increases susceptibility to infections and chronic diseases in the elderly.
- The precise mechanisms underlying immunosenescence are not fully understood.
Purpose of the Study:
- To review the key aspects of immunosenescence.
- To explore the potential of nutritional interventions in mitigating immunosenescence.
- To enhance the quality of life for the elderly population.
Main Methods:
- Literature review focusing on immunosenescence.
- Analysis of evidence for nutritional impacts on immune aging.
- Synthesis of current knowledge on immunosenescence mechanisms.
Main Results:
- Immunosenescence affects both innate and adaptive immunity.
- Reduced immune cell populations and impaired function are characteristic.
- Evidence suggests nutrition can influence the aging immune system.
Conclusions:
- Immunosenescence is a significant factor in age-related health decline.
- Nutritional strategies show promise in potentially delaying immunosenescence.
- Further research into nutritional interventions could improve elderly health outcomes.
Related Concept Videos
01:25Immunodeficiency Diseases
3.7K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
3.7K
01:22Development of Immunocompetence
1.2K
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.2K
01:26Factors Affecting the Risk of Infection
14.1K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.1K
01:28Chronic Kidney Disease III: Interprofessional Care
679
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
679
01:19The Effect of Aging on Tissues
3.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.6K
01:27Parentral Nutrition: Centeral and Peripheral Parental Nutrition
2.0K
Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
2.0K