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Updated: May 4, 2026
Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
Published on: October 27, 2014
Case numbers for a randomized clinical trial of boron neutron capture therapy for Glioblastoma multiforme
Anja Sander1, Werner Wosniok1, Detlef Gabel2
1Kompetenzzentrum Klinische Studien KKS, Bremen, Germany; Cooperative Center Medicine, University of Bremen, Bremen, Germany.
Abstract:
Boron neutron capture therapy (BNCT) with Na2B12H11SH (BSH) or p-dihydroxyborylphenylalanine (BPA), and with a combination of both, was compared to radiotherapy with temozolomide, and the number of patients required to show statistically significant differences between the treatments was calculated. Whereas arms using BPA require excessive number of patients in each arm, a two-armed clinical trial with BSH and radiotherapy plus temozolomide is feasible.
