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Tumor suppressor p53 and its mutants in cancer metabolism

Juan Liu1, Cen Zhang1, Wenwei Hu2

  • 1Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, New Brunswick, NJ 08903, USA.

Cancer Letters
|December 31, 2013
PubMed

Insights

The tumor suppressor p53 (also known as TP53) regulates cellular metabolism to prevent cancer. Mutant p53 proteins can hijack these metabolic functions to promote tumor growth.

Area of Science:

  • Molecular Biology
  • Oncology
  • Metabolic Regulation

Background:

  • The p53 protein (TP53) is a critical tumor suppressor involved in stress responses like apoptosis and cell cycle arrest.
  • Metabolic dysregulation is a hallmark of cancer, significantly contributing to tumor development.
  • Recent research highlights p53's role in regulating cellular metabolism, crucial for its tumor-suppressive functions.

Purpose of the Study:

  • To review the multifaceted roles of wild-type and mutant p53 in metabolic regulation.
  • To elucidate the mechanisms by which p53 influences cellular metabolism.
  • To discuss the implications of p53's metabolic functions in tumorigenesis.

Main Methods:

  • Literature review of recent studies on p53 and metabolic regulation.
  • Analysis of p53's transcriptional targets involved in metabolic pathways.
  • Examination of gain-of-function activities of mutant p53 in cancer metabolism.

Main Results:

  • Wild-type p53 maintains metabolic homeostasis by regulating glycolysis, oxidative phosphorylation, and fatty acid metabolism.
  • Mutant p53 proteins exhibit gain-of-function activities, promoting tumorigenesis through altered metabolic pathways.
  • p53's metabolic regulatory functions are integral to its tumor suppression capabilities.

Conclusions:

  • p53 is a key regulator of cellular metabolism, essential for tumor suppression.
  • Mutant p53 actively promotes cancer development by dysregulating tumor metabolism.
  • Targeting p53's metabolic functions presents potential therapeutic strategies for cancer treatment.
Keywords:
MetabolismMutant p53Tumor suppressorp53

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