Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Inhibitors of Viral Protein Synthesis

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...

Inhibitors of Bacterial Protein Synthesis

Inhibitors of Bacterial Protein Synthesis

Aminoglycosides constitute a highly potent class of bactericidal antibiotics that exert their antimicrobial effects by targeting the bacterial ribosome, specifically disrupting protein synthesis. These polycationic molecules consist of amino-modified sugars linked via glycosidic bonds to an aminocyclitol core such as 2-deoxystreptamine or streptamine. Their strong positive charges facilitate tight binding to the negatively charged phosphate backbone of ribosomal RNA (rRNA), primarily at the 16S...

Viral Meningitis

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Luteolin mitigates inflammatory organ injury by targeting XIAP to block PANoptosis and mitochondrial dysfunction.

International immunopharmacology·2026

Same author

Bile Acid-Mediated Interactions with Various Cell Types in the Cholestatic Liver.

DNA and cell biology·2025

Same author

Activation and Stabilization Strategies of Aluminum Metal Anode Toward High Performance Aqueous Al Metal Batteries.

Advanced materials (Deerfield Beach, Fla.)·2025

Same author

Environmental risk factors, protective factors, and biomarkers for amyotrophic lateral sclerosis: an umbrella review.

Frontiers in aging neuroscience·2025

Same author

Investigation of Polarity Reversal of Bilayer AlN/Sc<sub>0.2</sub>Al<sub>0.8</sub>N Films and Its Influence on Film Bulk Acoustic Resonators.

Small methods·2025

Same author

Impacts of feeding different lipid sources on serum biochemical indices, dietary fatty acid metabolism, raw foie gras quality characteristics and gene expression related to fat deposition in the Landes goose.

Animal nutrition (Zhongguo xu mu shou yi xue hui)·2025

Search research articles

Related Experiment Video

Updated: May 4, 2026

Fluorescence-based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals

Fluorescence-based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals

Published on: April 15, 2017

Suramin inhibits EV71 infection.

Yaxin Wang¹, Jie Qing², Yuna Sun¹

¹National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing 100101, China.

Antiviral Research

|December 31, 2013

Summary

This summary is machine-generated.

Suramin, a drug used for other diseases, effectively inhibits Enterovirus-71 (EV71) proliferation by blocking viral attachment to host cells. This finding offers a potential new antiviral therapy for EV71 infections, a cause of severe hand-foot-and-mouth disease.

Keywords:

Antiviral Enterovirus 71 Suramin

More Related Videos

Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment

Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment

Published on: March 2, 2016

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

Related Experiment Videos

Last Updated: May 4, 2026

Fluorescence-based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals

Fluorescence-based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals

Published on: April 15, 2017

Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment

Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment

Published on: March 2, 2016

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

Area of Science:

Virology
Infectious Diseases
Drug Discovery

Background:

Enterovirus-71 (EV71) is a primary cause of hand-foot-and-mouth disease, frequently leading to severe central nervous system infections and fatalities.
Current therapeutic options for EV71 are limited, with no specific antiviral agents available despite ongoing vaccine development.

Purpose of the Study:

To identify potential antiviral agents against EV71 from a compound library.
To investigate the mechanism of action of identified compounds on EV71 infection.

Main Methods:

Screening of a compound library to identify EV71 inhibitors.
Determination of the IC50 value for identified compounds.
Analysis of the effect of compounds on EV71 attachment and other lifecycle stages.

Main Results:

Suramin was identified as an inhibitor of EV71 proliferation with an IC50 value of 40 μM.
Suramin was shown to inhibit EV71 attachment to host cells, impacting early infection stages.
The drug also affected other phases of the EV71 life cycle.

Conclusions:

Suramin demonstrates significant antiviral activity against Enterovirus-71.
The mechanism involves blocking viral attachment and potentially other steps in the EV71 lifecycle.
Suramin, an existing drug, represents a promising candidate for repurposing as an antiviral treatment for EV71 infections.