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Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
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Primary (autoimmune) hypophysitis: a single centre experience.

Shruti Khare1, Varsha S Jagtap, Sweta R Budyal

  • 1Department of Endocrinology, Seth G S Medical College, KEM Hospital, Parel, Mumbai, 400012, India, shrutigkhare@yahoo.co.in.

Pituitary
|December 31, 2013
PubMed
Summary
This summary is machine-generated.

Autoimmune hypophysitis (AH) is a rare pituitary disorder. Characteristic radiology aids AH diagnosis, and non-operative management is preferred, with steroid pulse therapy potentially improving pituitary axis recovery.

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Area of Science:

  • Endocrinology
  • Immunology
  • Radiology

Background:

  • Autoimmune hypophysitis (AH) is a rare inflammatory disorder affecting the pituitary gland.
  • It is often diagnosed as a diagnosis of exclusion.

Purpose of the Study:

  • To analyze the clinical, hormonal, and radiological features of autoimmune hypophysitis.
  • To evaluate the management outcomes for patients with AH.

Main Methods:

  • Retrospective analysis of patients diagnosed with primary hypophysitis between 2006 and 2012.
  • Inclusion criteria involved ruling out secondary causes of hypophysitis.

Main Results:

  • Twenty-four patients (21 female, 3 male) with AH were evaluated.
  • Common presentations included expanding sellar mass (83.3%), anterior pituitary hormone deficiencies (58.3%), and diabetes insipidus (16.7%).
  • Magnetic resonance imaging (MRI) revealed symmetrical, enhancing sellar masses in most patients, with characteristic findings like stalk thickening and loss of posterior pituitary hyperintensity.
  • Sellar masses regressed in all patients post-treatment. Hormone replacement was standard; 20.83% underwent surgery, 62.5% were monitored, and 16.67% received steroid pulse therapy.
  • Pituitary hormone axis recovery was observed in 41.67% of patients, particularly for cortisol and gonadotropin axes.

Conclusions:

  • Characteristic radiological findings can aid in diagnosing AH, even without tissue confirmation.
  • Non-operative management is the preferred treatment strategy for AH.
  • Steroid pulse therapy may enhance pituitary axis recovery in AH patients.