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Multimodal Optical Imaging Platform for Studying Cellular Metabolism
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Cell tracking using multimodal imaging.

Mangala Srinivas1, Ignacio Melero, Eckhart Kaempgen

  • 1Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Department of Tumor Immunology, Nijmegen, The Netherlands.

Contrast Media & Molecular Imaging
|December 31, 2013
PubMed
Summary

Multimodal cell tracking enhances cellular therapeutics by combining imaging techniques. This review explores labels, strategies, and challenges, focusing on MRI, to improve in vivo imaging sensitivity and reagent availability.

Keywords:
MRIPETSPECTbioluminescencecell trackingfluorescencein vivo imagingmultimodal

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Area of Science:

  • Biomedical Imaging
  • Cellular Therapeutics
  • Medical Diagnostics

Background:

  • In vivo imaging is crucial for tracking cells, especially in optimizing cellular therapeutics.
  • Multimodality imaging, combining multiple imaging techniques, is a growing trend for enhanced cell tracking.
  • This approach offers data corroboration and complementary information within a single experiment.

Purpose of the Study:

  • To review current labels and imaging strategies for multimodal cell tracking.
  • To discuss the advantages and disadvantages of various approaches, with a specific focus on Magnetic Resonance Imaging (MRI).
  • To identify limitations and future directions in the field.

Main Methods:

  • Literature review of existing studies on multimodal cell tracking.
  • Analysis of different labeling strategies and imaging techniques.
  • Focus on MRI-compatible labels and methods.

Main Results:

  • Various labels and imaging strategies exist for multimodal cell tracking.
  • MRI offers unique advantages but faces limitations in sensitivity and approved reagents.
  • Current methods are not always sensitive enough for all applications.

Conclusions:

  • Multimodal imaging significantly enhances cell tracking for therapeutic applications.
  • Addressing sensitivity limitations and developing novel, approved reagents are critical for progress.
  • Emerging in vitro and preclinical developments show promise for overcoming current challenges in in vivo multimodal imaging.