Related Experiment Video
Updated: May 4, 2026

11:44
Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
Published on: October 2, 2018
10.0K
Karlotoxin synthetic studies: concise synthesis of a C(42-63) B-ring tetrahydropyran fragment
Takashi Tomioka1, Yusuke Takahashi1, Toshihide Maejima1
1Department of Chemistry and Biochemistry, University of Mississippi, University, MS 38677, USA.
Tetrahedron Letters
|December 31, 2013
Abstract:
Starting from natural D-mannose, a C(42-63) B-ring tetrahydropyran fragment in karlotoxin 2 has been prepared via a common THP intermediate in a concise manner. E-selective Julia-Kocienski olefination efficiently assembled a C(51-63) chlorodiene subunit and a C(42-50) tetrahydropyran segment.

