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Angiogenesis from mononuclear cells in thrombi.

H J Leu, W Feigl, M Susani

Virchows Archiv. A, Pathological Anatomy and Histopathology

|January 1, 1987

Summary

Angiogenesis within thrombi can occur independently of the vascular wall, as mononuclear cells differentiate into endothelial cells. This process involves cell migration and the formation of new blood channels within the clot.

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Area of Science:

Cardiovascular Biology
Hematology
Cell Biology

Background:

Thrombus organization is a complex process involving new blood vessel formation (angiogenesis).
The origin of endothelial cells within organizing thrombi has been a subject of investigation.
Vasa vasorum invasion from the vascular wall is one proposed mechanism for thrombus angiogenesis.

Purpose of the Study:

To investigate the mechanisms of angiogenesis in organizing thrombi.
To determine if mononuclear cells contribute to endothelialization within thrombi.
To compare angiogenesis originating from mononuclear cells versus vasa vasorum invasion.

Main Methods:

Immunohistological analysis of thrombus samples.
Ultrastructural examination of cellular differentiation and organization.
Observation of the sequential development of vascular channels within the thrombus matrix.

Main Results:

Angiogenesis within thrombi is not solely dependent on vasa vasorum invasion.
Mononuclear cells within the thrombus differentiate into endothelial-like cells.
These cells form new channels lined by cells with endothelial characteristics, including Weibel-Palade bodies.
Vasa vasorum sprouting also occurs in areas of thrombus adjacent to the vessel wall.
In intact vessels, capillary invasion precedes mononuclear cell-derived angiogenesis.

Conclusions:

Mononuclear cells are a significant source of endothelial cells for thrombus organization.
Angiogenesis within thrombi can occur via intrinsic mechanisms involving cell differentiation.
Both intrinsic mononuclear cell differentiation and extrinsic vasa vasorum invasion contribute to thrombus angiogenesis.

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