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Human parechovirus infection, Denmark

Thea K Fischer, Sofie Midgley, Camilla Dalgaard

    Emerging Infectious Diseases
    |January 1, 2014
    PubMed

    Insights

    Human parechoviruses (HPeVs) can cause severe illness in young children. This study found HPeV in 3.0% of Danish children, with young infants at highest risk and a 6% mortality rate.

    Area of Science:

    • Virology
    • Pediatrics
    • Infectious Diseases

    Background:

    • Human parechoviruses (HPeVs) are known to cause severe illness in young children.
    • Understanding the epidemiology and clinical impact of HPeV is crucial for public health.

    Purpose of the Study:

    • To determine the prevalence and characteristics of Human parechovirus (HPeV) infections in children in Denmark.
    • To identify risk factors and outcomes associated with HPeV infection.

    Main Methods:

    • National surveillance was conducted from January 2009 to December 2012 in Denmark.
    • Cerebrospinal fluid, fecal, and tissue samples from 4,804 children were screened for HPeV RNA.
    • Detected HPeV RNA in 202 specimens (3.0%) from 149 individuals.

    Main Results:

    • Young infants were identified as the highest-risk group for HPeV infection.
    • A mortality rate of 6% (9 children) was observed among HPeV-infected children.
    • HPeV3 was the predominant genotype, with five distinct clades circulating during the study period.

    Conclusions:

    • HPeV infection poses a significant risk to young children, particularly infants.
    • The findings highlight the importance of continued surveillance and understanding of HPeV epidemiology.
    • This study provides valuable insights into the clinical and molecular aspects of HPeV in a pediatric population.

    Keywords:
    DenmarkHPeVchildreninfantsmeningitisparechovirusphylogeneticviruses

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