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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
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Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

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Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
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COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
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Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

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Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
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Updated: May 4, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

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Psoriasis and lasting implications.

Sudesh S Raju1

  • 1Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, 231 S. 34th Street, Philadelphia, PA 19104-6323, USA.

Expert Review of Clinical Immunology
|January 1, 2014
PubMed
Summary
This summary is machine-generated.

Psoriasis is a chronic immune disorder affecting skin and joints, linked to genetics and environmental triggers. Understanding its molecular progression is key to developing effective treatments for this widespread condition.

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Area of Science:

  • Immunology
  • Dermatology
  • Genetics

Background:

  • Psoriasis is a chronic immunological disease impacting skin and joints.
  • It involves genetic predisposition and environmental triggers activating immune responses.
  • The condition leads to inflammation, plaques, and significantly affects patient well-being.

Discussion:

  • Reviews various psoriasis types and their distinct characteristics.
  • Examines genetic and environmental factors initiating the immune cascade.
  • Details the molecular pathways driving psoriasis development.

Key Insights:

  • Psoriasis involves complex interplay between genetic susceptibility and environmental factors.
  • Immune system dysregulation is central to disease pathogenesis.
  • The progression leads to visible skin plaques and joint inflammation.

Outlook:

  • Discusses current therapeutic strategies for managing psoriasis.
  • Explores emerging treatments and future research directions.
  • Highlights the need for comprehensive management addressing physical and mental health impacts.