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Early brain development toward shaping of human mind: an integrative psychoneurodevelopmental model in prenatal and

Radovan Hruby1, Lili M Maas2, P G Fedor-Freybergh3

  • 1Institute of Prenatal and Perinatal Psychology, Medicine and Integrative Neuroscience, St. Elizabeth University College of Health and Social Work, Bratislava, Slovakia. radhru@gmail.com.

Neuro Endocrinology Letters
|January 1, 2014
PubMed

Insights

This study presents an integrative model of human brain and mind development, incorporating prenatal factors, molecular biology, and early life interactions. It highlights how these elements shape complex cognitive abilities and neurobehavioral strategies from gestation through infancy.

Area of Science:

  • Integrative neuroscience
  • Developmental psychology
  • Molecular biology
  • Psychoimmuno-neuroendocrinology

Background:

  • Human brain development is a complex process influenced by numerous prenatal and perinatal factors.
  • Early neuro-ontogenic processes are increasingly understood through advanced imaging techniques.
  • Genetic, epigenetic, and hormonal factors play critical roles in neurodevelopment.

Purpose of the Study:

  • To introduce an integrative psychoneurodevelopmental model for complex human brain and mind development.
  • To discuss key factors influencing neural development from fetal stages to early postnatal life.
  • To emphasize the interdisciplinary approach required for advancing brain and mind research.

Main Methods:

  • Review of latest findings in prenatal and perinatal medicine.
  • Analysis of structural 3D magnetic resonance imaging and diffusion tensor imaging of fetal brains.
  • Integration of data from molecular biology, genetics, epigenetics, and psychoimmuno-neuroendocrinology.

Main Results:

  • Identified critical factors including birth weight variability, fetal programming, and neurobehavioral states.
  • Highlighted the role of gene families, transcription factors, and epigenetic mechanisms in neurodevelopment.
  • Emphasized the impact of hormones (e.g., glucocorticoids), prenatal stress, and mother-newborn interactions on brain development.

Conclusions:

  • The integrative model provides a comprehensive framework for understanding human brain and mind development.
  • Early life experiences and biological factors profoundly shape cognitive abilities and neurobehavioral strategies.
  • This research supports personalized medicine, prevention, and treatment strategies in developmental neuroscience.

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