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Updated: May 4, 2026

Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry
Published on: June 26, 2019
Viruses and the nucleolus: the fatal attraction
1Centre International de Recherche en Infectiologie (CIRI, International Center for Infectiology Research), Inserm U1111, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Université de Lyon, 46 Allée d'Italie, 69365 Lyon CEDEX, France; LabEx Ecofect, Université de Lyon, 69007 Lyon, France.
Viruses interact with the nucleolus, a key cell component, altering its functions to promote viral replication. This review explores virus-nucleolus interactions and their role in disease.
Area of Science:
- Cell Biology
- Virology
- Molecular Biology
Background:
- The nucleolus is a critical cellular organelle involved in ribosome biogenesis and other vital functions.
- Viral infections frequently disrupt nucleolar structure and dynamics.
- Understanding these interactions is crucial for comprehending viral pathogenesis.
Purpose of the Study:
- To review the interactions between various viral families and the nucleolus.
- To highlight how these interactions influence viral replication and pathogenesis.
- To connect nucleolar functions and dysfunctions with viral diseases.
Main Methods:
- Literature review of studies on virus-nucleolus interactions.
- Analysis of viral component localization within the nucleolus.
- Examination of host nucleolar protein redistribution and modification during infection.
Main Results:
- Numerous viral components are found to localize within the nucleolus during infection.
- Viral infections cause significant alterations in nucleolar structure and protein composition.
- Host nucleolar proteins are often redistributed or modified, and non-nucleolar proteins accumulate in the nucleolus.
Conclusions:
- The nucleolus is a common target for viral manipulation.
- Virus-nucleolus interactions play a significant role in viral replication and disease development.
- Further research into these interactions could reveal new therapeutic targets for viral diseases.
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