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Studying Organelle Dynamics in B Cells During Immune Synapse Formation
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Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling

Marcus R Clark1, Malay Mandal1, Kyoko Ochiai2

  • 1Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Illinois 60637, USA.

Nature Reviews. Immunology
|January 1, 2014
PubMed

The development of B cells is dependent on the sequential DNA rearrangement of immunoglobulin loci that encode subunits of the B cell receptor. The pathway navigates a crucial checkpoint that ensures expression of a signalling-competent immunoglobulin heavy chain before commitment to rearrangement and expression of an immunoglobulin light chain. The checkpoint segregates proliferation of pre-B cells from immunoglobulin light chain recombination and their differentiation into B cells. Recent advances have revealed the molecular circuitry that controls two rival signalling systems, namely the interleukin-7 (IL-7) receptor and the pre-B cell receptor, to ensure that proliferation and immunoglobulin recombination are mutually exclusive, thereby maintaining genomic integrity during B cell development.

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