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Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

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Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
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The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...
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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and have instructions for its functioning. The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).
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Can we decipher the information content contained within cyclic nucleotide signals?

Thomas C Rich1, Kristal J Webb, Silas J Leavesley

  • 1Center for Lung Biology, 2 Department of Pharmacology, 3 Basic Medical Sciences Graduate Program, and 4 Department of Pharmacology, College of Medicine; and 5 Department of Chemical and Biomolecular Engineering, 6 College of Engineering, University of South Alabama, Mobile, AL 36688.

The Journal of General Physiology
|January 1, 2014
PubMed
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No abstract available in PubMed .

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