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Sensitivity and specificity can change in opposite directions when new predictive markers are added to risk models

Ben Van Calster1,2, Ewout W Steyerberg3, Ralph B D'Agostino2,4

  • 1KU Leuven Department of Development and Regeneration, Leuven, Belgium (BVC).

Medical Decision Making : an International Journal of the Society for Medical Decision Making
|January 1, 2014
PubMed

Keywords:
biomarkersdecision-analytic measuresnet benefitnet reclassification improvementrelative utilityrisk assessmentrisk factorssensitivity and specificity

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