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Updated: May 4, 2026
An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
Ambient temperature and respiratory virus infection.
Natalie Pica1, Nicole M Bouvier
1From the *Department of Microbiology; and †Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine, Mount Sinai, New York, NY.
Temperature significantly influences the spread of pediatric respiratory viruses, impacting their seasonal outbreaks. Understanding this relationship aids in predicting and managing childhood respiratory infections.
Area of Science:
- Virology
- Epidemiology
- Environmental Health
Background:
- Pediatric respiratory viruses exhibit distinct seasonal circulation patterns.
- Environmental factors are hypothesized to drive this seasonality.
- Temperature is a key environmental factor influencing viral transmission.
Purpose of the Study:
- To review the impact of temperature on the epidemicity of respiratory viruses.
- To synthesize epidemiological and laboratory findings on temperature and viral seasonality.
- To explore potential mechanisms linking temperature to viral seasonality.
Main Methods:
- Review of large-scale meta-analyses on respiratory virus epidemiology.
- Analysis of laboratory data from animal models.
- Synthesis of proposed mechanisms for viral seasonality.
Main Results:
- Temperature affects the circulation patterns of various pediatric respiratory viruses.
- Epidemiological data and animal models provide evidence for temperature's role.
- Multiple mechanisms explain how temperature influences viral spread and seasonality.
Conclusions:
- Temperature is a critical determinant of respiratory virus seasonality in children.
- Understanding temperature-virus interactions is essential for public health strategies.
- Further research into specific mechanisms can improve disease prediction and control.
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