Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations01:15

Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations

386
Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...
386
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

423
Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
423
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

408
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
408
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

1.0K
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
1.0K
IV Infusion to Oral Dosing: Conversion Methods01:28

IV Infusion to Oral Dosing: Conversion Methods

212
The development of extended-release formulations has facilitated the transition from intravenous to oral medication, offering a more convenient and patient-friendly approach to drug administration. This transition, however, requires careful management to ensure that therapeutic drug levels are maintained, preserving efficacy and avoiding adverse effects. Understanding pharmacokinetic principles and dosage calculations is critical during this process.Pharmacokinetics of the...
212
Estimation of k and VD of Aminoglycosides01:20

Estimation of k and VD of Aminoglycosides

335
Aminoglycosides are a class of antibiotics used to treat various bacterial infections. Clinicians must determine the elimination rate constant (k) and volume of distribution (VD) to optimize therapeutic efficacy and minimize toxicity. The k value represents the rate at which the drug is removed from the body, and the VD reflects the degree to which the drug distributes into body tissues. Accurately estimating these parameters allows healthcare professionals to tailor drug dosing to individual...
335

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Flucloxacillin plasma and urinary concentrations with and without probenecid and urinary biomarker profiles in healthy volunteers.

British journal of clinical pharmacology·2026
Same author

The Evolving Epidemiology of Invasive Pneumococcal Disease in Australian Children: A Multicentre Retrospective Observational Study.

Open forum infectious diseases·2026
Same author

Cefazolin for Methicillin-Susceptible <i>Staphylococcus aureus</i> Bacteremia.

The New England journal of medicine·2026
Same author

Tobramycin pharmacokinetic and pharmacodynamic targets in people with cystic fibrosis.

British journal of clinical pharmacology·2026
Same author

Tacrolimus in Pediatric Solid Organ Transplant Recipients: A Retrospective Cohort Study.

Pediatric transplantation·2026
Same author

Identification of antibiotic allergies in children using prescribing patterns in the electronic medical record.

British journal of clinical pharmacology·2026

Related Experiment Video

Updated: May 4, 2026

Continuous IV Infusion is the Choice Treatment Route for Arginine-vasopressin Receptor Blocker Conivaptan in Mice to Study Stroke-evoked Brain Edema
08:44

Continuous IV Infusion is the Choice Treatment Route for Arginine-vasopressin Receptor Blocker Conivaptan in Mice to Study Stroke-evoked Brain Edema

Published on: September 1, 2016

8.4K

Neonatal vancomycin continuous infusion: still a confusion?

Amanda Gwee1, Noel Cranswick, David Metz

  • 1From the *Department of General Medicine, The Royal Children's Hospital Melbourne; †Infectious Diseases & Microbiology group, Murdoch Childrens Research Institute; ‡Department of Paediatrics, The University of Melbourne; §Centre for International Health, Burnet Institute; ¶Department of Epidemiology and Preventive Medicine, Monash University; and ‖Department of Microbiology, The Royal Children's Hospital Melbourne, Victoria, Australia.

The Pediatric Infectious Disease Journal
|January 1, 2014
PubMed
Summary

Continuous vancomycin infusions in neonates are well tolerated and may improve target concentration attainment. This method requires less blood sampling compared to intermittent dosing, suggesting potential benefits for neonatal care.

More Related Videos

A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically
11:28

A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically

Published on: September 9, 2015

33.2K
A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
06:18

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

4.4K

Related Experiment Videos

Last Updated: May 4, 2026

Continuous IV Infusion is the Choice Treatment Route for Arginine-vasopressin Receptor Blocker Conivaptan in Mice to Study Stroke-evoked Brain Edema
08:44

Continuous IV Infusion is the Choice Treatment Route for Arginine-vasopressin Receptor Blocker Conivaptan in Mice to Study Stroke-evoked Brain Edema

Published on: September 1, 2016

8.4K
A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically
11:28

A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically

Published on: September 9, 2015

33.2K
A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
06:18

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

4.4K

Area of Science:

  • Neonatal Pharmacology
  • Infectious Disease Management
  • Pharmacokinetics

Background:

  • Continuous vancomycin infusion in adults offers benefits like reduced toxicity and improved drug concentration attainment.
  • Neonatal vancomycin dosing lacks a standardized consensus.
  • Evidence for continuous vancomycin infusion in neonates requires assessment.

Purpose of the Study:

  • To review existing literature on continuous vancomycin dosing regimens in neonates.
  • To evaluate the attainment of target serum drug concentrations with continuous infusions.
  • To assess the safety and tolerability of continuous vancomycin infusion in neonates.

Main Methods:

  • Literature search of Medline and Embase databases for relevant studies.
  • Inclusion of five prospective studies reporting serum vancomycin concentrations.
  • Analysis of studies using non-linear mixed effects modeling.

Main Results:

  • Continuous vancomycin infusions were generally well-tolerated in neonates.
  • Attainment of target vancomycin concentrations ranged from 56% to 89%.
  • Continuous infusion showed higher target concentration attainment (82%) compared to intermittent dosing (46%).

Conclusions:

  • Continuous vancomycin infusion is a viable option for neonates, demonstrating good tolerability.
  • This method may lead to more consistent achievement of therapeutic vancomycin levels.
  • Further research is recommended to solidify optimal continuous infusion protocols for neonates.