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Pediatric nephrologists' beliefs regarding randomized controlled trials

Aaron G Wightman1, Assaf P Oron, Jordan M Symons

  • 1From the *Division of Nephrology, Department of Pediatrics, University of Washington School of Medicine; †Division of Nephrology, Seattle Children's Hospital; and ‡Core for Biomedical Statistics, Seattle Children's Hospital, Seattle, WA.

Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
|January 1, 2014
PubMed

Insights

Pediatric nephrologists with less experience are less likely to enroll patients in randomized controlled trials (RCTs). Improving training and resources may boost participation in pediatric nephrology clinical research.

Area of Science:

  • Pediatric Nephrology
  • Clinical Research
  • Medical Education

Background:

  • Pediatric nephrology lags behind adult medicine in randomized controlled trial (RCT) production.
  • Physician attitudes significantly impact RCT enrollment rates.
  • Understanding these attitudes is crucial for improving pediatric clinical trial participation.

Purpose of the Study:

  • To investigate the attitudes of pediatric nephrologists towards randomized controlled trials (RCTs).
  • To identify factors influencing their decisions to recommend RCT enrollment for patients.
  • To explore differences in attitudes based on practice experience.

Main Methods:

  • Survey distributed to members of the American Society of Pediatric Nephrology.
  • Regression analyses used to determine predictors of RCT-friendly attitudes.
  • Data collected on beliefs about RCTs and influencing factors.

Main Results:

  • 130 responses received; 66% had enrolled patients in RCTs.
  • Longer practice duration ( >15 years) correlated with higher RCT enrollment.
  • Willingness to recommend RCTs increased for multicenter studies, sicker patients, or with participant financial incentives.

Conclusions:

  • Many pediatric nephrologists, especially early-career ones, have not enrolled patients in RCTs.
  • Lack of prior enrollment is linked to less favorable attitudes towards RCTs.
  • Enhanced training and resources could improve participation among junior providers in pediatric nephrology research.
Abstract

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