Related Experiment Video
Updated: May 4, 2026

DamID-seq: Genome-wide Mapping of Protein-DNA Interactions by High Throughput Sequencing of Adenine-methylated DNA Fragments
Published on: January 27, 2016
LIM-domain-only proteins: multifunctional nuclear transcription coregulators that interacts with diverse proteins
Meixiang Sang1, Li Ma, Meijie Sang
1Tumor Research Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050017, Hebei, People's Republic of China.
Abstract:
The LIM-only subclass of LIM proteins is a family of nuclear transcription co-regulators that are characterized by the exclusive presence of two tandem LIM domains and no other functional domains. To date, four LIM-domain-only (LMO) proteins (LMO1-LMO4) have been identified. They regulate gene transcription by functioning as "linker" or "scaffolding" proteins with a remarkable potential to mediate protein-protein interactions. These proteins play important roles in cell fate determination, cell growth and differentiation, tissues patterning, and organ development. In this review, we briefly described the functions of LMO proteins in the organ development and diseases. We also summarized the interaction proteins of each LMO family member, which may contribute to elucidating the functions of these mysterious and important linker proteins.
More Related Videos
Related Concept Videos
Co-activators and Co-repressors
Co-activators and Co-repressors
Cooperative Binding of Transcription Regulators
Cooperative Binding of Transcription Regulators
RNA Polymerase II Accessory Proteins
RNA Polymerase II Accessory Proteins

