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At the revolution with Fred Sherman.

Kenneth S Zaret1

  • 1Institute of Regenerative Medicine, Epigenetics Program, Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

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Summary

This minireview reflects on Fred Sherman, a key figure in yeast genetics, and his lab during the exciting recombinant DNA revolution. It covers the period from 1977 to 1982, highlighting a transformative era in molecular biology.

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Area of Science:

  • Genetics
  • Molecular Biology
  • Microbiology

Background:

  • Fred Sherman was a distinguished yeast geneticist.
  • The author was a graduate student under Sherman's mentorship from 1977 to 1982.
  • This period coincided with major advancements in recombinant DNA technology.

Purpose of the Study:

  • To provide a personal account of working in Fred Sherman's yeast genetics lab.
  • To capture the excitement of the recombinant DNA revolution's impact on yeast genetics.
  • To commemorate Fred Sherman's contributions to the field.

Main Methods:

  • Personal reminiscences and anecdotal evidence.
  • Historical context of the recombinant DNA revolution.
  • Focus on the specific period of 1977-1982 in yeast genetics research.

Main Results:

  • The minireview offers insights into the laboratory environment and scientific atmosphere of the time.
  • It highlights the integration of new recombinant DNA techniques into yeast genetics.
  • The narrative conveys the intellectual vibrancy and collaborative spirit of Sherman's lab.

Conclusions:

  • The period 1977-1982 was a pivotal time for yeast genetics, driven by recombinant DNA technology.
  • Fred Sherman's lab was at the forefront of these exciting developments.
  • The author shares a personal perspective on this significant era in scientific history.