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Updated: May 4, 2026
Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
Published on: October 4, 2024
Quality control of positron emission tomography radiopharmaceuticals: An institutional experience
Jaya Shukla1, Rakhee Vatsa1, Nitasha Garg1
1Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India.
Purpose Of The Study:
To study quality control parameters of routinely prepared positron emission tomography (PET) radiopharmaceuticals.
Materials And Methods:
Three PET radiopharmaceuticals fluorine-18 fluorodeoxyglucose (F-18 FDG), N-13 ammonia (N-13 NH3), and Ga-68 DOTATATE (n = 25 each), prepared by standardized protocols were used. The radionuclide purity, radiochemical purity, residual solvents, pH, endotoxins, and sterility of these radiopharmaceuticals were determined.
Results:
The physical half-life of radionuclide in radiopharmaceuticals, determined by both graphical and formula method, demonstrated purity of radionuclides used. pH of all PET radiopharmaceuticals used was in the range of 5-6.5. No microbial growth was observed in radiopharmaceutical preparations. The residual solvents, chemical impurity, and pyrogens were within the permissible limits.
Conclusions:
All three PET radiopharmaceuticals were safe for intravenous administration.
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