Bone scintigraphy in Ollier's disease: A rare case report

Area of Science:

• Oncology
• Genetics
• Radiology

Background:

• Ollier's disease is a rare skeletal dysplasia characterized by enchondromas.
• Existing literature suggests associations between Ollier's disease and vascular malformations or non-skeletal neoplasms.
• The full spectrum of potential comorbidities remains incompletely understood.

Observation:

• This report details a unique case of Ollier's disease in a young male.
• The patient presented with multiple enchondromas, osteochondromas, a low-grade glioma in the insular cortex, and Gilbert's syndrome.
• This constellation of findings represents a novel association.

Findings:

• Technetium-99m methylene diphosphonate whole body bone scan proved highly sensitive.
• The scan accurately identified the extent of skeletal involvement, including asymptomatic sites.
• This imaging modality is crucial for comprehensive assessment in Ollier's disease.

Implications:

• This case expands the known clinical spectrum associated with Ollier's disease.
• It highlights the importance of considering non-skeletal comorbidities in patients with Ollier's disease.
• Comprehensive imaging, like bone scintigraphy, is vital for complete disease staging and management planning.