Acute cholestatic hepatitis caused by amoxicillin/clavulanate
Daniel Oliveira Beraldo1, Joanderson Fernandes Melo1, Alexandre Vidal Bonfim1
1Daniel Oliveira Beraldo, Joanderson Fernandes Melo, Alexandre Vidal Bonfim, Andrei Alkmim Teixeira, Ricardo Alkmim Teixeira, Department of Internal Medicine, Hospital Renascentista, Pouso Alegre, MG 37550-000, Brazil.
World Journal of Gastroenterology
|January 1, 2014
Summary
Amoxicillin/clavulanate, an antibiotic, can rarely cause liver injury. A case of cholestatic hepatitis developed in a patient after prolonged use, resolving spontaneously without specific treatment.
Area of Science:
- Hepatology
- Pharmacology
Background:
- Amoxicillin/clavulanate is a widely prescribed oral antibiotic for bacterial infections.
- While generally safe, it is associated with potential adverse effects, including hepatic complications.
Observation:
- A 63-year-old male presented with cholestatic hepatitis and severe hyperbilirubinemia after 6 weeks of amoxicillin/clavulanate use.
- Diagnostic workup included imaging, serological tests, and liver biopsy.
Findings:
- The patient exhibited signs of cholestatic icterus and elevated bilirubin levels.
- Symptoms and laboratory abnormalities resolved completely within 4 months.
- No specific treatment for hepatitis was administered, only supportive care for symptoms.
Implications:
- This case highlights a rare but serious adverse effect of amoxicillin/clavulanate.
- Physicians should consider drug-induced liver injury in patients presenting with cholestatic hepatitis.
- Further research may be needed to elucidate the mechanisms of amoxicillin/clavulanate-induced hepatotoxicity.
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