Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.6K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K
Glaucoma: Overview01:25

Glaucoma: Overview

1.7K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.7K
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

615
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
615
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

343
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
343

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Use of Sustained Release Intravitreal Steroid Implants in Non-Infectious Uveitis Affecting the Posterior Segment of the Eye.

Ophthalmology and therapy·2022
Same author

Intravitreal dexamethasone implant Ozurdex in the treatment of diabetic macular edema in patients not previously treated with any intravitreal drug: a prospective 12-month follow-up study.

Current medical research and opinion·2019
Same author

Birdshot chorioretinopathy.

Current opinion in ophthalmology·2014
Same author

Dexamethasone implants in retinal vein occlusion: 12-month clinical effectiveness using repeat injections as-needed.

The British journal of ophthalmology·2013
Same author

Intraocular methotrexate can induce extended remission in some patients in noninfectious uveitis.

Retina (Philadelphia, Pa.)·2013
Same author

Dexamethasone implants and neovascular glaucoma in central retinal vein occlusion.

Acta ophthalmologica·2012

Related Experiment Video

Updated: May 4, 2026

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology
06:19

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology

Published on: May 31, 2024

1.9K

Birdshot uveitis: current and emerging treatment options.

Victor Menezo1, Simon Rj Taylor2

  • 1Institut Catala de Retina, Barcelona, Spain ; Department of Ophthalmology, Provincial Hospital Consortium Castellon, Castello, Spain.

Clinical Ophthalmology (Auckland, N.Z.)
|January 1, 2014
PubMed
Summary

Birdshot chorioretinopathy, linked to HLA-A29, is diagnosed clinically by characteristic fundus lesions. Despite advances, immune mechanisms are unclear, necessitating personalized medicine for better visual outcomes.

Keywords:
HLA-A29Th17 cellsbirdshot chorioretinopathyinterleukin antagonistsmonoclonal antibodiesretinal vasculitis

More Related Videos

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
10:33

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

4.3K
Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
07:40

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

5.3K

Related Experiment Videos

Last Updated: May 4, 2026

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology
06:19

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology

Published on: May 31, 2024

1.9K
Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
10:33

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

4.3K
Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
07:40

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

5.3K

Area of Science:

  • Ophthalmology
  • Immunology
  • Genetics

Background:

  • Birdshot chorioretinopathy is a rare form of idiopathic posterior uveitis.
  • It is strongly associated with the Human Leukocyte Antigen (HLA)-A29 allele.
  • Diagnosis is clinical, based on characteristic hypopigmented choroidal lesions.

Purpose of the Study:

  • To investigate the unclear immune mechanisms in birdshot chorioretinopathy pathogenesis.
  • To improve phenotyping and monitoring for early identification of patients at risk of visual loss.
  • To explore targeted therapies, including newer biological agents, for improved patient outcomes.

Main Methods:

  • Clinical diagnosis based on characteristic fundus findings.
  • Genetic association studies focusing on HLA-A29.
  • Ongoing laboratory research into disease mechanisms.
  • Clinical research for improved phenotyping and monitoring.

Main Results:

  • Central visual acuity can be preserved until late stages.
  • Inadequate immunosuppressive treatment can lead to poor long-term outcomes.
  • Newer therapies, like biological agents, show improved control of inflammation in refractory cases.

Conclusions:

  • Despite advances, immune mechanisms remain unclear.
  • Personalized medicine approaches are crucial for identifying at-risk patients.
  • Targeted therapies offer hope for improved visual function in birdshot chorioretinopathy.