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Glycosilated fetal hemoglobin in neonates of diabetic mothers
Insights
Fetal glycosilated hemoglobin (HbF1) in cord blood can identify newborns at risk from diabetic mothers. Higher HbF1 levels indicate poorer maternal glycemic control during pregnancy, signaling increased infant risk.
Area of Science:
- Neonatal Medicine
- Endocrinology
- Biochemistry
Background:
- Diabetic patients exhibit a known correlation between glycosilated adult hemoglobin (HbA1c) and average glucose levels.
- Assessing fetal glycosilated hemoglobin (HbF1) in neonates of diabetic mothers offers a potential method for risk identification.
Purpose of the Study:
- To investigate the utility of fetal glycosilated hemoglobin (HbF1) in cord blood for identifying newborns at risk from diabetic pregnancies.
Main Methods:
- Fetal glycosilated hemoglobin (HbF1) levels were measured in the cord blood of neonates using the isoelectric focusing technique.
- Comparison of HbF1 levels between infants of diabetic mothers and normal newborns.
Main Results:
- Mean HbF1 values were significantly higher in infants born to diabetic mothers compared to healthy neonates.
- The highest HbF1 levels were observed in neonates whose mothers had poor glycemic control in late pregnancy.
Conclusions:
- Cord blood HbF1 levels serve as a potential biomarker for identifying neonates at risk due to maternal diabetes.
- Elevated HbF1 correlates with maternal glycemic control, highlighting its significance in neonatal risk assessment.
Abstract:
In diabetic patients, the correlation between glycosilated adult hemoglobin (HbA1c) levels and average glucose concentration over the preceding weeks is well known. We have, therefore, sought the possibility to identify newborns at risk measuring cord blood levels of fetal glycosilated hemoglobin (HbF1) in neonates of diabetic mothers. HbF1 was tested by the isoelectrofocusing method. Mean values of HbF1 have been proven to be higher in in infants born to diabetic mothers as compared to normal newborns. The highest levels were encountered in those babies whose mothers had shown a poor glycemic control during the last few weeks of pregnancy.