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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
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Links demystified: Periodontitis and cancer
Gowri Pendyala1, Saurabh Joshi2, Shantanu Chaudhari2
1Department of Periodontics, Rural Dental College, Loni, Maharashtra, India.
Dental Research Journal
|January 1, 2014
Summary
Periodontal disease, an oral infection causing chronic inflammation, is linked to increased cancer risk. This review explores the biological mechanisms connecting oral inflammation and various cancers.
Area of Science:
- Oncology
- Periodontology
- Immunology
Background:
- Cancer is characterized by uncontrolled cell growth, invasion, and metastasis.
- Inflammation is increasingly recognized as a critical factor in tumor progression and the tumor microenvironment.
- Periodontal disease is a chronic oral inflammatory condition linked to systemic effects and increased circulating inflammatory markers.
Purpose of the Study:
- To review and summarize the potential biological mechanisms linking periodontal infection and cancer.
- To highlight the association between periodontal disease and various cancers, including lung, kidney, pancreas, hematological, and oral cancers.
Main Methods:
- Literature review of studies investigating the relationship between periodontal disease and cancer.
- Analysis of biological mechanisms, including the role of inflammation and the tumor microenvironment.
Main Results:
- Periodontal infection can lead to systemic inflammation, influencing cancer development and progression.
- The tumor microenvironment, orchestrated by inflammatory cells, supports cancer cell proliferation, survival, and migration.
- Documented associations exist between periodontal disease and increased risk for several types of cancer.
Conclusions:
- Periodontal disease may contribute to cancer development and progression through inflammatory pathways.
- Understanding these biological mechanisms is crucial for potential therapeutic and preventive strategies.
- Further research is warranted to elucidate the complex interplay between oral health and cancer.
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