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Updated: May 4, 2026

Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury
Published on: September 7, 2018
Hemostatic profile and thromboembolic risk in healthy dogs treated with prednisone: a randomized controlled trial
Felipe Gazza Romão1, Elza Fernanda Campos, Claudio Roberto Scabelo Mattoso
1Department of Veterinary Clinics, Botucatu Veterinary Medicine School, University Estadual Paulista - UNESP, Botucatu, Brazil. fgazza_vet@hotmail.com.
Background:
Thrombosis has been associated to some diseases like hyperadrenocorticism (HAC). Several drugs can alter the balance, such as the corticosteroid prednisone, used mainly for its anti-inflammatory and immunosuppressive effects. It is known that hypercortisolism can stimulate thrombi formation by increasing coagulation factors and decreasing fibrinolysis. However it is not known how prednisone administration affects hemostasis in dogs and if it is dose dependent. The aim of this study, therefore, was to demonstrate the effects of prednisone administration on dogs' hemostatic profile.
Results:
Significant decrease of antithrombin levels was observed in both groups (anti-inflammatory and immunosuppressive doses) after 15 days of treatment. An increase of platelet aggregation was observed in dogs receiving immunosuppressive doses of prednisone (Group II).
Conclusions:
From the results obtained in our study, it is not possible to infer that hypercortisolism can increase the thromboembolic risk, despite the decreased anticoagulant factors (antithrombin levels).
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