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Discovery of 2-pyridineformamide thiosemicarbazones as potent antiausterity agents
Bhushan Shakya1, Paras Nath Yadav1, Jun-ya Ueda2
1Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu, Nepal.
Abstract:
Series of 2-pyridineformamide thiosemicarbazones were synthesized. Their preferential cytotoxicity in nutrient deprived medium (NDM) was evaluated using PANC-1 human pancreatic cancer cells by employing an antiausterity strategy. 2-Pyridineformamide thiosemicarbazones induced apoptosis and exhibited preferential cytotoxic activity toward PANC-1 cells in NDM, with potencies in the submicromolar range. These compounds are potential candidates for the development of therapeutics against pancreatic cancer.
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