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Updated: May 4, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
Published on: September 14, 2010
Multicentric Castleman's disease and HIV
John R Krause1, Sara D Robinson1, Estil A Vance1
1Department of Pathology, Section of Hematopathology (Krause), and the Department of Hematology/Oncology (Robinson, Vance), Baylor University Medical Center at Dallas and the Baylor Charles A. Sammons Cancer Center at Dallas.
Abstract:
Multicentric Castleman's disease (MCD) is a rare lymphoproliferative disorder found with a higher frequency in HIV-seropositive patients. Human herpes virus 8 is found in virtually all cases of HIV-associated MCD. The majority of cases of MCD in patients with HIV are also associated with Kaposi's sarcoma. The dysregulated production of human IL-6 is thought to be an important factor in the pathogenesis of MCD. HIV-seropositive individuals with MCD have a significantly greater risk of developing non-Hodgkin lymphomas than their HIV-seronegative counterparts. MCD occurring in HIV patients has been associated with a poor prognosis. With newer therapy regimens, it is hoped that the prospects of HIV-infected patients with MCD will improve.
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