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Related Experiment Video

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Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Published on: November 17, 2018

Interactions between Nod-Like Receptors and Intestinal Bacteria.

Marcel R de Zoete¹, Richard A Flavell²

¹Department of Immunobiology, Yale University School of Medicine , New Haven, CT , USA.

Frontiers in Immunology

|January 2, 2014

Summary

Nucleotide oligomerization domain (Nod)-like Receptors (NLRs) are key sensors in the gut. This review explores their role in bacterial infections and maintaining gut microbiota balance.

Keywords:

inflammasome intestine microbiota nod-like receptors pathogen

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An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions

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Published on: June 30, 2021

Area of Science:

Immunology
Microbiology
Gastroenterology

Background:

Nucleotide oligomerization domain (Nod)-like Receptors (NLRs) are intracellular sensors.
NLRs activate Caspase-1, leading to pro-inflammatory cytokines IL-1β and IL-18 release.
NLRs also induce pyroptosis, a form of inflammatory cell death.

Purpose of the Study:

To review the role of intestinal NLRs in bacterial infections.
To understand NLR function in controlling gut microbiota.

Main Methods:

Literature review of studies on NLRs and gastrointestinal bacteria.
Analysis of NLR activation during pathogenic and commensal bacterial colonization.

Main Results:

In vitro studies show various bacteria activate NLRs.
The in vivo impact of NLR activation during colonization is less understood.
NLRs play a role in host defense against pathogens and microbiota homeostasis.

Conclusions:

Intestinal NLRs are crucial for sensing bacterial threats.
NLRs influence host-pathogen interactions and gut microbiome composition.