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Atherogenic dyslipidemia.

C N Manjunath1, Jayesh R Rawal2, Paurus Mehelli Irani3

  • 1Department of cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore, India.

Indian Journal of Endocrinology and Metabolism
|January 2, 2014
PubMed
Summary
This summary is machine-generated.

Atherogenic dyslipidemia (AD), common in Asian Indians, involves unhealthy lipid levels and increases cardiovascular disease risk. Lifestyle changes and medications like rosuvastatin are key to managing AD, especially in diabetes and metabolic syndrome patients.

Keywords:
Atherogenic dyslipidaemiacardiovascular diseasesmall-dense low-density lipoprotein statins

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Area of Science:

  • Cardiovascular Medicine
  • Metabolic Disorders
  • Lipidology

Background:

  • Atherogenic dyslipidemia (AD) is characterized by elevated triglycerides (TG), small-dense low-density lipoprotein (LDL), and low high-density lipoprotein cholesterol (HDL-C).
  • AD involves increased very-low-density lipoproteins, apolipoprotein B, and oxidized LDL, alongside reduced small HDL particles, all independent cardiovascular disease (CVD) risk factors.
  • The LDL-C/HDL-C ratio is a superior predictor of coronary heart disease risk compared to individual markers.

Purpose of the Study:

  • To highlight the critical role of AD in cardiovascular disease.
  • To explain the higher prevalence of AD in Asian Indians due to lifestyle factors.
  • To outline management strategies for AD, including lifestyle modifications and pharmacotherapy.

Main Methods:

  • Review of existing literature on AD pathophysiology, risk factors, and management.
  • Analysis of lipid profiles and their association with cardiovascular risk.
  • Evaluation of therapeutic interventions, including lifestyle changes and drug therapies.

Main Results:

  • AD is a significant independent risk factor for cardiovascular disease.
  • Asian Indians exhibit a higher prevalence of AD linked to physical inactivity and dietary patterns low in polyunsaturated fatty acids (PUFA).
  • Therapeutic lifestyle changes (increased physical activity, exercise, PUFA-rich diets) are primary interventions, often supplemented by statins, niacin, or fibrates.

Conclusions:

  • AD management is crucial for reducing cardiovascular risk, particularly in Asian Indian populations.
  • Lifestyle modifications, including diet and exercise, are foundational for treating AD.
  • Rosuvastatin is identified as a specific statin effective for AD in patients with diabetes and metabolic syndrome (MS).