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Updated: May 4, 2026
Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
Published on: August 1, 2018
Receptor status of tumor as prognostic factor in patients with bilateral breast cancer
D Y Tsyhyka1, Y S Hotko1, O T Devinyak1
1Uzhgorod National University, Uzhgorod 88000, Ukraine.
Aim:
To determine the receptor status of tumors as prognostic factor in development of bilateral breast cancer (BBC) and factor of prognosis of disease.
Patients And Methods:
272 cases of BBC during the period from 1995 to 2011 in different oncological institutions of Ukraine have been analyzed.
Results:
Patients with metachronous BBC with positive status of hormone receptors (HR) of tumors have significantly better indices of overall and progression-free survival (three-years - 95%, five-years - 72%), than patients with HR-negative status (among them nobody has survived over 5 years). In patients with synchronous BBC, the receptor status of tumors has similar influence on the prognosis of survival. Nevertheless, indices of overall survival (65%) and progression-free survival (66%) in HR-positive patients were lower than that at metachronous BBC (overall survival and progression-free survival - 72%).
Conclusions:
Synchronous breast cancer has more aggressive clinical course than metachronous one. It was determined significant influence of receptor status of tumors on the overall survival and progression-free survival in patients with BBC.
