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Flow Cytometry

Flow Cytometry

The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
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Updated: May 4, 2026

Enumeration of Major Peripheral Blood Leukocyte Populations for Multicenter Clinical Trials Using a Whole Blood Phenotyping Assay

Enumeration of Major Peripheral Blood Leukocyte Populations for Multicenter Clinical Trials Using a Whole Blood Phenotyping Assay

Published on: September 16, 2012

High-throughput flow cytometry data normalization for clinical trials.

Greg Finak¹, Wenxin Jiang, Kevin Krouse

¹Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109.

Cytometry. Part a : the Journal of the International Society for Analytical Cytology

|January 3, 2014

Summary

This summary is machine-generated.

This study introduces a computational framework for normalizing flow cytometry data in clinical trials. The local normalization method improves accuracy and efficiency in analyzing large datasets, reducing manual gating variability.

Failed At:

2026-06-19T13:37:01.735257+00:00

Keywords:

BioConductor bias immunology staining variability template gating

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