Rasburicase for acute kidney injury
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Updated: May 4, 2026

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
Published on: November 3, 2023
1Vision Care Hospital and Institute of Child Health, Kolkata, India. Correspondence to: Dr Rajiv Sinha, 37, G Bondel Road, Kolkata 700 019, India. rajivsinha_in@yahoo.com.
Background:
Acute kidney injury (AKI) continues to have significant mortality and morbidity and the search is on for any novel therapeutic intervention.
Case Characteristics:
Two cases of AKI with elevated SUA (serum uric acid).
Intervention:
Rasburicase.
Outcome:
In Case 1 (late preterm male with AKI) rasburicase resulted in a significant reduction of SUA along with improvement in renal parameters. In Case 2 (6 yrs old boy with multi organ failure), rasburicase failed to provide any significant benefit despite fall in SUA.
Message:
The effect of rasburicase in AKI needs to be studied.
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