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Related Concept Videos

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Multipotency of Hematopoietic Stem Cells01:19

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Stem Cell Niche01:26

Stem Cell Niche

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Related Experiment Video

Updated: May 4, 2026

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
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Stem cells, redox signaling, and stem cell aging.

Raymond Liang1, Saghi Ghaffari

  • 11 Department of Developmental & Regenerative Biology, Icahn School of Medicine at Mount Sinai , New York, New York.

Antioxidants & Redox Signaling
|January 4, 2014
PubMed
Summary

Reactive oxygen species (ROS) regulate stem cell aging and tissue homeostasis. Understanding ROS

Area of Science:

  • Cellular Biology
  • Aging Research
  • Stem Cell Science

Background:

  • Redox metabolism influences stem cell pool and aging.
  • Reactive oxygen species (ROS) act as physiological signaling mediators, not just damaging agents.

Purpose of the Study:

  • To review ROS regulation of stem cell fate.
  • To explore the role of ROS in stem cell aging and associated diseases.

Main Methods:

  • Review of published literature on ROS signaling pathways.
  • Analysis of transcription factors regulated by ROS.
  • Focus on alterations implicated in stem cell aging diseases.

Main Results:

  • ROS regulate key signaling pathways and transcription factors controlling stem cell fate.

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  • Dysregulation of ROS signaling is linked to stem cell aging.
  • A model is proposed where ROS act as a 'stem cell rheostat'.

    • Conclusions:

    • Elucidating ROS control over stem cell cycling, apoptosis, and lineage determination is crucial.
    • This research sheds light on mechanisms of stem cell aging.
    • Understanding ROS is vital for combating age-related diseases.