Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Survival Curves01:18

Survival Curves

931
Survival curves are graphical representations that depict the survival experience of a population over time, offering an intuitive way to track the proportion of individuals who remain event-free at each time point. These curves are widely used in fields such as medicine, public health, and reliability engineering to visualize and compare survival probabilities across different groups or conditions.
The Kaplan-Meier estimator is the most common method for constructing survival curves. This...
931
Parametric Survival Analysis: Weibull and Exponential Methods01:14

Parametric Survival Analysis: Weibull and Exponential Methods

1.3K
Parametric survival analysis models survival data by assuming a specific probability distribution for the time until an event occurs. The Weibull and exponential distributions are two of the most commonly used methods in this context, due to their versatility and relatively straightforward application.
Weibull Distribution
The Weibull distribution is a flexible model used in parametric survival analysis. It can handle both increasing and decreasing hazard rates, depending on its shape parameter...
1.3K
Noncompartmental Analysis: Mean Residence Time01:05

Noncompartmental Analysis: Mean Residence Time

727
According to statistical moment theory, mean residence time (MRT) is an important measure in pharmacokinetics. MRT can be defined as the expected mean of a probability density function distribution. It provides valuable insights into drug disposition in the body.
After the administration of a drug through intravenous bolus injection, the drug molecules are distributed throughout the body and remain there for varying periods. The MRT represents the average time these drug molecules stay in the...
727
The Integrated Rate Law: The Dependence of Concentration on Time02:39

The Integrated Rate Law: The Dependence of Concentration on Time

36.0K
While the differential rate law relates the rate and concentrations of reactants, a second form of rate law called the integrated rate law relates concentrations of reactants and time. Integrated rate laws can be used to determine the amount of reactant or product present after a period of time or to estimate the time required for a reaction to proceed to a certain extent. For example, an integrated rate law helps determine the length of time a radioactive material must be stored for its...
36.0K
Noncompartmental Analysis: Statistical Moment Theory00:56

Noncompartmental Analysis: Statistical Moment Theory

524
Noncompartmental analyses leverage statistical moment theory to examine time-related changes in macroscopic events, encapsulating the collective outcomes stemming from the constituent elements in play. Statistical moment theory is a mathematical approach used to describe the time course of drug concentration in the body without assuming a specific compartmental model. SMT provides insights into drug absorption, distribution, metabolism, and elimination by treating drug concentration versus time...
524
Measuring Reaction Rates03:09

Measuring Reaction Rates

23.5K
Polarimetry finds application in chemical kinetics to measure the concentration and reaction kinetics of optically active substances during a chemical reaction. Optically active substances have the capability of rotating the plane of polarization of linearly polarized light passing through them—a feature called optical rotation. Optical activity is attributed to the molecular structure of substances. Normal monochromatic light is unpolarized and possesses oscillations of the electrical...
23.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multicenter dose de-escalation phase I trial of pressurized intraperitoneal aerosolized chemotherapy (PIPAC) nab-paclitaxel and cisplatin in combination with systemic nab-paclitaxel in recurrent ovarian cancer patients: trial in progress.

Pleura and peritoneum·2026
Same author

Primate gut microbiota induce evolutionarily salient changes in mouse neurodevelopment.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Correction: Senguttuvan et al. The Anti-Cancer Role of Pterostilbene in Endometrial Cancer: A Phase II Prospective, Randomized, Window-of-Opportunity Clinical Trial with Megestrol Acetate. <i>Antioxidants</i> 2025, <i>14</i>, 345.

Antioxidants (Basel, Switzerland)·2025
Same author

Divergent oncogenic signaling and immune microenvironment changes in low-grade serous ovarian cancer patients undergoing intraperitoneal chemotherapy.

NPJ precision oncology·2025
Same author

ASO Visual Abstract: Safety and Efficacy of Cisplatin and Doxorubicin Pressurized Intraperitoneal Aerosolized Chemotherapy (PIPAC) in Ovarian Cancer Patients with Peritoneal Metastases-A Multicenter U.S. Phase I Trial.

Annals of surgical oncology·2025
Same author

Safety and Efficacy of Cisplatin and Doxorubicin Pressurized Intraperitoneal Aerosolized Chemotherapy (PIPAC) in Patients with Ovarian Cancer with Peritoneal Metastases: A Multicenter US Phase I Trial.

Annals of surgical oncology·2025
Same journal

Review of Glypican-3-Targeted Imaging Agents for Hepatocellular Carcinoma.

Cancer biotherapy & radiopharmaceuticals·2026
Same journal

Clinical Laboratory Evaluation of the Biodistribution of a Radiolabeled Antimicrobial Peptide for Precision Radiopharmaceutical-Guided Radionuclide Therapy in Severe Pneumonia Among Immunocompromised Patients with Cancer.

Cancer biotherapy & radiopharmaceuticals·2026
Same journal

Single-Cell Transcriptomics in Triple-Negative Breast Cancer: Implications for Radionuclide Therapy in Precision Oncology.

Cancer biotherapy & radiopharmaceuticals·2026
Same journal

Curved Vertebroplasty System Combined with Targeted Radionuclide Therapy for Tumor-Related Pathological Vertebral Fractures.

Cancer biotherapy & radiopharmaceuticals·2026
Same journal

Development of a Freeze-Dried Bevacizumab Kit for <sup>99m</sup>Tc Radiolabeling and Preclinical Evaluation <i>In Vitro</i> and in Normal Mice.

Cancer biotherapy & radiopharmaceuticals·2026
Same journal

Radionuclide-Based Theranostic Mapping for Spatially Optimized Treatment Planning in Cervical Carcinoma.

Cancer biotherapy & radiopharmaceuticals·2026
See all related articles

Related Experiment Video

Updated: May 4, 2026

Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking
14:21

Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking

Published on: August 6, 2013

18.0K

Using a single parameter to describe time-activity curves.

Cheuk S Kwok1, Paul H Frankel, George Lopatin

  • 11 Division of Cancer Immunotherapy and Tumor Immunology, City of Hope National Medical Center , Duarte, California.

Cancer Biotherapy & Radiopharmaceuticals
|January 4, 2014
PubMed
Summary
This summary is machine-generated.

Engineered antibodies

More Related Videos

Author Spotlight: A Novel Setup to Conduct Naturalistic Laboratory Experiments with Real Human Actors in Scenarios
07:43

Author Spotlight: A Novel Setup to Conduct Naturalistic Laboratory Experiments with Real Human Actors in Scenarios

Published on: August 4, 2023

2.8K
Trajectory Data Analyses for Pedestrian Space-time Activity Study
16:14

Trajectory Data Analyses for Pedestrian Space-time Activity Study

Published on: February 25, 2013

13.4K

Related Experiment Videos

Last Updated: May 4, 2026

Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking
14:21

Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking

Published on: August 6, 2013

18.0K
Author Spotlight: A Novel Setup to Conduct Naturalistic Laboratory Experiments with Real Human Actors in Scenarios
07:43

Author Spotlight: A Novel Setup to Conduct Naturalistic Laboratory Experiments with Real Human Actors in Scenarios

Published on: August 4, 2023

2.8K
Trajectory Data Analyses for Pedestrian Space-time Activity Study
16:14

Trajectory Data Analyses for Pedestrian Space-time Activity Study

Published on: February 25, 2013

13.4K

Area of Science:

  • Radiopharmaceutical kinetics
  • Pharmacokinetics
  • Biotechnology

Background:

  • Time-activity uptake curves require complex functional forms for analysis.
  • Comparing engineered radiopharmaceuticals necessitates efficient descriptors.
  • Mean Residence Time (MRT) offers a simplified, one-parameter approach.

Purpose of the Study:

  • To evaluate the utility of Mean Residence Time (MRT) and residence time (τ) for characterizing engineered antibodies.
  • To compare the pharmacokinetic profiles of intact and engineered anti-carcinoembryonic antigen (CEA) antibodies.
  • To assess blood and tumor exposure for potential therapeutic applications.

Main Methods:

  • Calculation of MRT for intact and engineered anti-CEA antibodies.
  • Analysis of MRT for engineered scFv-Fc fragments.
  • Assignment of residence time (τ) using uptake functions for tumor site analysis.
  • Utilized a human xenograft model in nude mice.

Main Results:

  • Intact anti-CEA antibodies exhibited significantly longer blood MRT compared to engineered forms (approx. 10-fold difference).
  • Engineered scFv-Fc fragments showed varied blood residence times, with a double mutant having 30-fold less residence time than wild type.
  • The intact anti-CEA antibody demonstrated the longest residence time at the tumor site.

Conclusions:

  • MRT and τ provide valuable metrics for comparing engineered antibody pharmacokinetics.
  • Differences in MRT are likely due to the absence of an intact Fc segment in engineered antibodies.
  • These concepts can potentially guide the development of unlabeled engineered antibodies for cancer treatment by comparing blood and tissue exposure.