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Analyzing and Building Nucleic Acid Structures with 3DNA
Published on: April 26, 2013
A 2D graphical representation of the sequences of DNA based on triplets and its application
Sai Zou, Lei Wang1, Junfeng Wang
1School of Software Engineering, Chongqing College of Electronic Engineering, Chongqing 401331, People's Republic of China. phd.leiwang@gmail.com.
Abstract:
In this paper, we first present a new concept of 'weight' for 64 triplets and define a different weight for each kind of triplet. Then, we give a novel 2D graphical representation for DNA sequences, which can transform a DNA sequence into a plot set to facilitate quantitative comparisons of DNA sequences. Thereafter, associating with a newly designed measure of similarity, we introduce a novel approach to make similarities/dissimilarities analysis of DNA sequences. Finally, the applications in similarities/dissimilarities analysis of the complete coding sequences of β-globin genes of 11 species illustrate the utilities of our newly proposed method.
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