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Updated: May 4, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
Published on: July 24, 2019
Serum melatonin is an alternative index of Parkinson's disease severity
Ling Lin1, Yuequn Du2, Sutao Yuan3
1Key Laboratory of Brain Aging and Neurodegenerative Diseases, Fujian Medical University, Fuzhou 350108, China; Department of Biochemistry and Molecular Biology, Fujian Medical University, Fuzhou 350108, China.
Abstract:
The protective potential of melatonin (MLT) in Parkinson's disease (PD) is the subject of considerable controversy. The purpose of the present study was to investigate serum MLT levels in unilateral 6-hydroxydopamine (6-OHDA) lesion rats and patients with PD. Blood samples were collected from rats at 10:00 am and from patients with PD and healthy subjects between 8:00 and 10:00 am. Serum MLT levels were measured using the enzyme-linked immunosorbent assay. Our results revealed that the morning serum MLT levels either in 6-OHDA-induced hemi-parkinsonian rats or patients with PD were significantly higher than that of control group. Our results also demonstrate that serum MLT levels are correlated with severity of PD according to H & Y scale.
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