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Related Concept Videos

Diversity of Protists II01:27

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Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
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Fission is the division of a single entity into two or more parts, which regenerate into separate entities that resemble the original. Organisms in the Archaea and Bacteria domains reproduce using binary fission, in which a parent cell splits into two parts that can each grow to the size of the original parent cell. This asexual method of reproduction produces cells that are all genetically identical.
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Binary fission is the primary mode of asexual reproduction in prokaryotes, such as bacteria. It results in the production of two genetically identical daughter cells. This highly efficient process ensures the rapid propagation of bacterial populations under favorable conditions and involves coordinated cellular and molecular events.DNA Replication and SeparationThe process begins with the replication of the bacterial chromosome. The circular DNA molecule unwinds at a specific origin of...
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Cytokinesis segregates a cell’s chromosomes and organelles into its daughter cells. Organelles divide and grow prior to cell division but cannot be synthesized de novo; therefore, cells must receive at least one copy of each organelle to survive. Currently, many of the details of how the organelles are distributed are not yet fully elucidated.
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Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function. 
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Amoebozoa represent a diverse group of terrestrial and aquatic protists that utilize lobe-shaped pseudopodia for locomotion and feeding. This characteristic differentiates them from the Rhizaria, which possess threadlike pseudopodia. The primary classifications within Amoebozoa include gymnamoebas, entamoebas, and the plasmodial and cellular slime molds. Phylogenetic evidence indicates that Amoebozoa diverged from a lineage that ultimately gave rise to fungi and animals.Gymnamoebas and...
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Cell division in apicomplexan parasites.

Maria E Francia1, Boris Striepen2

  • 1Department of Cellular Biology, University of Georgia, Athens, Georgia 30602, USA.

Nature Reviews. Microbiology
|January 4, 2014
PubMed
Summary
This summary is machine-generated.

The centrosome may regulate apicomplexan cell division by tethering cellular components. This provides spatial and temporal control for parasites like Toxoplasma gondii and Plasmodium falciparum.

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Area of Science:

  • Parasitology
  • Cell Biology
  • Molecular Biology

Background:

  • Toxoplasma gondii and Plasmodium falciparum are significant human pathogens.
  • Apicomplexan parasites exhibit complex developmental cycles within host cells, involving replication, division, and stage assembly.
  • Cell cycle progression in apicomplexans is regulated both globally (cytoplasmic factors) and locally (nuclear/daughter cell development).

Purpose of the Study:

  • To investigate the role of the centrosome in regulating apicomplexan cell division.
  • To propose a model where the centrosome acts as a master regulator of parasite cell cycle.

Main Methods:

  • This study is primarily theoretical, proposing a regulatory model based on existing knowledge of apicomplexan cell biology.
  • The proposed mechanism involves the centrosome's function in physically tethering cellular components.

Main Results:

  • The centrosome is hypothesized to provide spatial and temporal control over apicomplexan cell division.
  • This regulation is proposed to occur at the local level, influencing individual nuclei and developing daughter cells.

Conclusions:

  • The centrosome is suggested to be a key regulator of cell division in apicomplexan parasites.
  • Understanding this centrosome-mediated regulation could offer new insights into controlling parasitic infections.