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Updated: May 4, 2026

Identification of MyoD Interactome Using Tandem Affinity Purification Coupled to Mass Spectrometry
Published on: May 17, 2016
An overview of MYC and its interactome
Maralice Conacci-Sorrell1, Lisa McFerrin, Robert N Eisenman
1Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109.
Abstract:
This review is intended to provide a broad outline of the biological and molecular functions of MYC as well as of the larger protein network within which MYC operates. We present a view of MYC as a sensor that integrates multiple cellular signals to mediate a broad transcriptional response controlling many aspects of cell behavior. We also describe the larger transcriptional network linked to MYC with emphasis on the MXD family of MYC antagonists. Last, we discuss evidence that the network has evolved for millions of years, dating back to the emergence of animals.
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