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Vascular angiotensin conversion in humans.

D J Webb, J G Collier

    Journal of Cardiovascular Pharmacology
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Ramiprilat, an angiotensin converting enzyme (ACE) inhibitor, significantly increased forearm blood flow in humans. This suggests ACE inhibition in resistance vessels may contribute to the blood pressure-lowering effects of ACE inhibitors.

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    Area of Science:

    • Pharmacology
    • Cardiovascular Physiology

    Background:

    • Angiotensin converting enzyme (ACE) inhibitors are widely used to treat hypertension.
    • The role of ACE within human resistance vessels is not fully understood.

    Purpose of the Study:

    • To investigate the effects of ramiprilat, an ACE inhibitor, on forearm blood flow (FBF) in normotensive and hypertensive individuals.
    • To determine if ACE is present and active in human forearm resistance vessels.

    Main Methods:

    • Brachial artery infusions of angiotensin I (ANG I), angiotensin II (ANG II), and ramiprilat were administered.
    • Forearm blood flow (FBF) was measured before, during, and after infusions.
    • Vascular responses to ANG I and ANG II were assessed before and after ramiprilat administration.

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    Main Results:

    • Ramiprilat infusion caused a significant 71% increase in FBF in vessels preconstricted with ANG I.
    • After ramiprilat, the dose of ANG I required to produce equivalent constriction increased 20-fold, while ANG II response was unaltered.
    • Ramiprilat alone produced a small, nonsignificant increase in FBF, which correlated with plasma renin levels.

    Conclusions:

    • These findings confirm the presence and activity of ACE within human resistance vessels.
    • Inhibition of ACE in peripheral vascular beds may contribute to the overall hypotensive effects of ACE inhibitors.