Related Experiment Video
Updated: May 4, 2026
Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation
Published on: February 15, 2018
Risk factors and outcome in neonatal necrotising enterocolitis
Bahubali Gane1, B Vishnu Bhat, B Adhisivam
1Division of Neonatology, Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, 605006, India.
Objectives:
To analyze multiple risk factors of necrotizing enterocolitis (NEC) and the outcome.
Methods:
Hundred neonates with NEC were compared with 100 normal neonates matched for sex, gestation and weight. Their data including antenatal, natal, course of illness, hospital stay, progress and outcome were collected. Univariate analysis and logistic regression were used to analyze the risk factors.
Results:
Mean age of onset of NEC was 2.35 ± 1.11 d. Stage I, II and III were noted in 48 %, 39 % and 13 % of cases respectively. Most common clinical features were abdominal distension (85 %) and feed intolerance (70 %). Important risk factors associated with NEC were sepsis, top feeding, perinatal asphyxia, respiratory distress and mechanical ventilation. Antenatal steroids and breast feeding had beneficial effect. No association was found with occurrence of NEC and cyanotic heart disease or administration of H2 blockers. Outcome in stage III was very poor.
Conclusions:
Early identification of risk factors and appropriate intervention may reduce the incidence and improve the outcome in NEC.
Related Concept Videos
01:26Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
01:07Intestinal Obstruction II: Pathophysiology
01:18Bacterial Gastroenteritis