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Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice
Published on: February 11, 2019
Intramesenteric steroid treatment for steroid- refractory gastrointestinal graft versus host disease
Aynur Uğur Bilgin1, Pervin Topcuoğlu2, Tanzer Sancak3
1Necmettin Erbakan University, Meram Faculty of Medicine, Division of Hematology, Department of Internal Medicine, Konya, Turkey.
Unlabelled:
Currently, steroid-refractory severe gastrointestinal (GI) graft versus host disease (GVHD) is among the most important complications of allogeneic transplantation, and as yet there is no standard approach to its treatment. Herein we report two cases with steroid-refractory GI GVHD that received intramesenteric steroid treatment. In both cases the frequency and volume of diarrhea resolved completely following intramesenteric methylprednisolone (MP) injection. In conclusion, intra-arterial steroid injection might be an alternative treatment approach for steroid-refractory GI GVHD.
Conflict Of Interest:
None declared.
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