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Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
Published on: April 21, 2017
Endothelial protein C receptor and pediatric arterial stroke
Nejat Akar1, Afife Karabıyık1, Gülhis Deda2
1Ankara University, School of Medicine, Department of Pediatric Molecular Genetics, Ankara, Turkey.
Objective:
The aim of this study was to investigate the endothelial protein C receptor (EPCR) gene A3 haplotype and plasma soluble EPCR (sEPCR) levels in Turkish pediatric arterial stroke patients.
Materials And Methods:
We analyzed 44 pediatric arterial stroke patients and 75 healthy controls. Following DNA isolation, genotyping of the A3 haplotype was determined via PCR and RFLP. Additionally, fasting sEPCR levels were determined via ELISA.
Results:
There wasn't a significant difference in the sEPCR level between the control and patient groups, although the sEPCR level was higher in the patient group. We didn't observe a difference in the distribution of the CC and CG/GG genotypes between the control and patient groups.
Conclusion:
Further study on sEPCR levels at the onset of pediatric stroke is needed in order to reach a more definitive conclusion.
Conflict Of Interest:
None declared.
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