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[Progress on mechanism of cell apoptosis induced by rubella virus]

Zhen-mei Li1, Fu-lu Chu2, Ying Liu2

  • 1Department of Virology, School of Public Health, Key Laboratory for Experimental Teratology of the Ministry of Education, Shandong University, Jinan 250012, China. meizi_chongzi@163.com

Bing Du Xue Bao = Chinese Journal of Virology
|January 7, 2014
PubMed

Insights

Rubella virus (RV) triggers host cell apoptosis through specific molecular pathways. This review details the mechanisms, including key protein kinases and p53/TAp63 roles in cell death signaling.

Area of Science:

  • Virology
  • Molecular Biology
  • Cell Biology

Context:

  • Rubella virus (RV), a Togaviridae family member, is known to induce programmed cell death (apoptosis) in host cells.
  • Understanding the molecular underpinnings of RV-induced apoptosis is crucial for comprehending viral pathogenesis.

Purpose:

  • To review the molecular mechanisms by which Rubella virus induces apoptosis in host cells.
  • To summarize the roles of key signaling pathways and proteins involved in RV-induced cell death.

Summary:

  • Rubella virus infection can lead to host cell apoptosis.
  • Protein kinases in the Ras-Raf-MEK-ERK and PI3K-Akt pathways are vital for RV multiplication, cell survival, and apoptosis.
  • Proteins p53 and TAp63 activate Bax, leading to mitochondrial cytochrome c release and caspase activation, key events in apoptosis.

Impact:

  • Provides a comprehensive overview of RV-induced apoptosis mechanisms.
  • Highlights the involvement of specific cellular signaling pathways and proteins in viral-induced cell death.
  • Contributes to the understanding of Rubella virus pathogenesis and potential therapeutic targets.

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