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Updated: May 4, 2026

Isolated Lung Perfusion System in the Rabbit Model
Published on: July 15, 2021
Time to adequate oxygenation following ventilation using the Enk oxygen flow modulator versus a jet ventilator via
Carrie F P Wong1, Vivian M Yuen, Gordon T C Wong
1Department of Anaesthesiology, Queen Mary Hospital, Hong Kong, China.
Introduction:
Limited information is available on the management of the 'cannot intubate, cannot ventilate' (CICV) situation in infants. We compared the time to achieve adequate oxygenation following rescue ventilation using the Enk oxygen flow modulator (OFM) with a jet ventilator in a simulated CICV situation using the rabbit as an infant respiratory model.
Methods:
Following institutional ethics committee approval, needle cricothyrotomy was performed under direct vision in nine anesthetized rabbits following surgical exposure of the larynx. After ensuring adequate level of anesthesia and analgesia, and confirming proper positioning of the 18G cannula, apnea was induced by the administration of myorelaxant and the SpO2 was allowed to drop to 75% before initiating rescue ventilation via either the OFM or jet ventilator.
Results:
Five rabbits were ventilated with the OFM and four with the jet ventilator. Ventilation was maintained with either device for 15 min. All rabbits were successfully rescued using either device. There was no statistical difference in the time required for SpO2 to return to 80%, 85%, 90%, and 95%.
Conclusions:
Both devices facilitated successful rescue ventilation through a needle cricothyrotomy.
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